Chronic pain: Medication decisions

Date Updated: 12/19/2024

Chronic pain is a serious health condition that can lead to complications beyond physical symptoms. People with chronic pain may experience depression, anxiety and trouble sleeping.

Chronic pain is pain that is long lasting. It can affect every aspect of life — from relationships to finances. Chronic pain makes it harder to keep up with work, tasks at home and social gatherings. Some research suggests that the worse the pain, the more serious the effects on day-to-day life.

For these reasons, finding effective treatment for chronic pain is important. But the process is complex and personal. What works for one person's chronic low back pain may not bring relief for another person's osteoarthritis.

There are a number of reasons for this. The cause of the chronic pain, a person's biology and history all play a role in pain management. And finding pain therapies that bring you relief can take time.

Working with your healthcare team can help you find treatments that allow you to live an enjoyable, fulfilling life. The approach you choose should include more than medication. But medications might play a role in pain management.

Learn about the risks and benefits of common pain medications. This can help you make safe choices as you look for a solution to chronic pain.

Nonsteroidal anti-inflammatory drugs, known as NSAIDs

NSAIDs are most effective for mild to moderate pain that occurs with swelling, known as inflammation. These medications are commonly used for arthritis and pain resulting from muscle sprains, strains, back and neck injuries, or menstrual cramps.

Generic (brand) names. Ibuprofen (Advil, Motrin IB, others); naproxen sodium (Aleve); others.
How they work. NSAIDs work by stopping certain enzymes in your body from being released due to tissue damage. These enzymes are called cyclooxygenase (COX). NSAIDs block different types of COX, including COX-1 and COX-2. As a result, NSAIDs help reduce pain and inflammation that result from an injury.
Benefits and risks. When taken as directed, NSAIDs are generally safe. But if you take more than the recommended dosage, NSAIDs may cause nausea, stomach pain, stomach bleeding or ulcers. Sometimes this can happen even when you take the recommended dosage.

Large doses of NSAIDs also can lead to trouble with kidney function, fluid retention and high blood pressure. Risks increase with age. Having other health conditions such as diabetes, a history of stomach ulcers or reflux, and kidney disease also raises the risk.
Bottom line. If you regularly take NSAIDs, talk to your health care provider. Your healthcare team can monitor you for possible side effects. NSAIDs also have a ceiling effect — a limit as to how much pain they can control. Taking more than the recommended dose may not relieve the pain and may increase the risk of serious side effects.

Acetaminophen

Acetaminophen is usually recommended first for mild to moderate pain. It might be taken for pain due to a skin injury, headache, or conditions that affect the muscles and bones. Acetaminophen is often prescribed to help manage osteoarthritis and back pain. It also may be combined with opioids to reduce the amount of opioid needed.

Generic (brand) names. Acetaminophen (Tylenol, others).
How it works. Acetaminophen is thought to block the production of prostaglandins in the central nervous system. Prostaglandins are hormonelike substances that are involved in pain and inflammation. Unlike NSAIDs, acetaminophen doesn't target inflammation at the site of injury — only pain.
Benefits and risks. Acetaminophen is generally considered safer than other pain relievers. It doesn't cause side effects such as stomach pain and bleeding. However, taking more than the recommended dose or taking acetaminophen with alcohol increases the risk of kidney damage and liver failure over time.
Bottom line. Acetaminophen is generally a safe option to try first for many types of pain, including chronic pain. Ask your healthcare professional for guidance about safely taking acetaminophen if you take other medications. Acetaminophen is not as effective as NSAIDs for the treatment of knee and hip pain related to osteoarthritis.

COX-2 inhibitors

COX-2 inhibitors are another type of NSAID. These medications were developed with the aim of reducing the common side effects of traditional NSAIDs. COX-2 inhibitors are commonly used for arthritis and pain resulting from muscle sprains, strains, back and neck injuries, or menstrual cramps. They are as effective as NSAIDs and may be the right choice with less risk of stomach damage.

Generic (brand) names. Celecoxib (Celebrex, Elyxyb).
How they work. COX-2 inhibitors work in a slightly different way than traditional NSAIDs. COX-2 inhibitors block only the COX-2 enzyme — the one that's more likely to cause pain and inflammation.
Benefits and risks. By acting only on COX-2 enzymes, they allow COX-1 enzymes to continue to function. COX-1 enzymes protect the lining of the stomach. NSAIDs, on the other hand, block COX-1 and can cause side effects such as thinning of the stomach lining. This can lead to ulcers and bleeding.

The risk of stomach bleeding tends to be lower if you take a COX-2 inhibitor, but bleeding can still occur. This is true especially at higher doses. And COX-2 inhibitors can lead to headaches, dizziness, high blood pressure, kidney problems, fluid retention and high blood pressure. These medications may increase the risk of a heart attack or stroke.
Bottom line. Older adults may be at higher risk of common COX-2 side effects compared with younger adults. If these medications help you manage chronic pain, aim to take the lowest effective dose for the shortest time possible. Follow up closely with your healthcare team.

Antidepressants and anti-seizure medications

Some medications commonly prescribed to manage depression and prevent seizures have been found to help relieve chronic pain. This is true especially for chronic nerve pain. They may help relieve back pain, fibromyalgia and diabetes-related nerve pain, known as diabetic neuropathy. Because chronic pain often worsens depression, antidepressants may offer the extra benefit of treating mood symptoms.

Generic (brand) names. Tricyclic antidepressants used in the treatment of chronic pain include amitriptyline and nortriptyline (Pamelor).

Serotonin and norepinephrine reuptake inhibitors, known as SNRIs, that may be prescribed to relieve chronic pain include duloxetine (Cymbalta, Drizalma Sprinkle), venlafaxine (Effexor XR) and milnacipran (Savella).

Anti-seizure medications used to treat chronic nerve pain include gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica). These medications treat the burning pain of shingles, known as postherpetic neuralgia. And they treat pain related to nerve damage in the legs and feet due to diabetes, known as diabetic neuropathy.
How they work. Anti-seizure medications quiet pain signals from nerve cells. They may be helpful for stabbing or shooting pain from nerve damage. These medications may take several weeks before you notice the effects.
Benefits and risks. Side effects of these medications are generally mild but may include nausea, dizziness or drowsiness. As a group, antidepressants and anti-seizure medications may, rarely, worsen depression or cause suicidal thoughts. If you notice changes in your thinking patterns or mood while taking these medications, talk with your healthcare professional right away.
Bottom line. To reduce the risk of side effects, your healthcare professional may start you on a small amount of these medications and gradually increase the dose. When it's time to stop taking them, work with your healthcare professional to gradually lower the dose before stopping the medication completelyYour healthcare professional likely will recommend that you take these medications before bedtime.

Opioids

Opioid medications are synthetic cousins of opium and the drugs derived from opium such as heroin and morphine. These medications are typically prescribed for pain that's new, known as acute pain. Acute pain can stem from an injury, such as surgery or a broken bone.

Opioids currently cause the most overdose deaths in the United States — and that rate is still rising. Because the risks are so great, opioids are used at the lowest dose possible, usually for just a few days.

Generic (brand) names. Hydrocodone (Hysingla ER); hydrocodone-acetaminophen; fentanyl; oxycodone (OxyContin, Roxicodone, others); oxycodone-acetaminophen (Percocet, Oxycet); others.
How they work. Opioids, like real opium, mimic the natural pain-relieving chemicals produced by the brain. These chemicals are called endorphins. The medications turn down the volume on the pain signals your nervous system sends through your body. They also muffle other nerve cell functions, such as breathing, heart rate and level of alertness.
Benefits and risks. Research shows that over time your body adapts to these medications and they bring less and less pain relief. This is known as tolerance. It means that you need more of the medication to achieve the same degree of pain relief. Long-term use of opioids may lead to dependence on the medications and, eventually, addiction.

The longer you use opioids, the greater the risk of becoming addicted. But even using opioids to manage pain for more than a few days increases your risk. Researchers have found that the odds of being on opioids a year after starting a short course increases after only five days on the medication.
Bottom line. Opioids are a last resort for chronic pain management. They may be the right choice for long-term pain related to cancer and its treatments. Rarely, opioids may be used for noncancer pain that hasn't responded to any other medications. Because the risks are serious, you'll need careful and frequent follow-ups with your healthcare professional if you use opioids long term.

While there isn't a cure for chronic pain, many effective pain medications are available to help reduce pain. As you try different medications, work with your healthcare professional to find the simplest long-term solution possible. Keep your medication risks to a minimum to help you enjoy many good days for many years to come.

Pain medications at a glance

Medication type	How they work	First line option for	Benefits	Risks
NSAIDs	Block COX-1 and COX-2 enzymes involved in pain and inflammation	Mild to moderate pain accompanied by swelling and inflammation Arthritis pain and pain resulting from muscle sprains and strains, back and neck injuries, overuse injuries, and menstrual cramps	When taken as directed, generally safe for short-term use Available without a prescription	May cause nausea, stomach pain, stomach bleeding or ulcers When taken in high doses, can lead to kidney problems, fluid retention and high blood pressure Increased risk of side effects for older adults
Acetaminophen	Thought to block prostaglandin production in the central nervous system	Mild to moderate pain	Available without a prescription	When more than the recommended dose is taken or when taken with alcohol, increased risk of kidney damage and liver failure over time
COX-2 inhibitors	Block COX-2 enzymes	Rheumatoid arthritis, osteoarthritis, menstrual cramps and injury-related pain	As effective as NSAIDs without damaging stomach lining at regular doses	Headache and dizziness When taken in high doses, can lead to stomach bleeding, kidney problems, fluid retention, high blood pressure, heart attack and stroke Increased risk of side effects for older adults
Antidepressants	Interfere with certain chemical processes that cause you to feel pain	Neuropathic pain, chronic headaches, fibromyalgia May be considered for chronic low back pain	Can be in doses much lower than what is currently used to treat depression Side effects generally mild, depending on the type of antidepressant	Drowsiness possible with tricyclic antidepressants Can take several weeks to produce desired effects May worsen depression and cause suicidal thoughts in a small number of people
Anti-seizure medications	Quiet pain signals from damaged nerves	The burning pain of shingles, known as postherpetic neuralgia; diabetic neuropathy; fibromyalgia	Side effects generally mild	May cause dizziness, drowsiness, nausea, reduced coordination and weight changes May worsen depression and cause suicidal thoughts in a small number of people
Opioids	Blocks opioid receptors, which stop the release of chemicals that cause pain Can stop the transmission of pain signals	Acute pain, such as pain that follows surgery or a bone fracture Typically prescribed for a few days or less	Powerful relief during short periods of severe pain	Feeling drowsy, nausea, itchiness, constipation Tolerance, dependence, misuse, addiction and overdose Taking opioids for longer than the prescribed length of time increases the risk of staying on them long term Responsible for the majority of overdose deaths in the U.S.