Chelation therapy for heart disease: Does it work?

Date Updated: 11/23/2021

Answer Section

It's unclear whether chelation therapy can treat heart disease.

Chelation therapy has long been used as a treatment for mercury and lead poisoning, but it isn't a proven treatment for heart disease. It can potentially cause serious side effects when used as a heart disease treatment. Even so, some health care providers have used chelation therapy to treat heart disease and stroke.

Chelation therapy involves weekly IV treatments of ethylenediaminetetraacetic acid (EDTA). Each treatment lasts about 30 minutes.

In general, the medication seeks out and sticks to metals and minerals in the bloodstream, creating a compound that the body removes when urinating. Chelation therapy is promoted as a treatment for heart disease because it's thought that the medicine sticks to calcium found in fatty deposits (plaques) in the arteries.

However, chelation therapy for heart disease remains controversial. Here's what we know so far:

The Trial to Assess Chelation Therapy (TACT) didn't provide enough evidence to support routine use for heart disease. But it did find that chelation therapy offered moderate protection against future cardiovascular events, such as strokes and heart attacks, in those with diabetes. TACT2 will focus specifically on people with diabetes.
The American Heart Association and the American College of Cardiology say it's uncertain whether chelation therapy is helpful as a treatment for heart disease.
The Food and Drug Administration hasn't approved chelation therapy for use as a heart disease treatment.

Chelation therapy for heart disease has known risks and side effects. The most common is burning at the IV site. Other side effects include fever, headache, nausea or vomiting.

Rare but serious complications of chelation therapy for heart disease that have been reported include:

Low blood-calcium levels (hypocalcemia)
Sudden drop in blood pressure
Drop in bone marrow counts (bone marrow suppression)
Heart failure
Kidney damage
Death

Before trying chelation therapy as a heart disease treatment, talk to your health care provider about the benefits and risks.